Joslin Investigator Details

A Harvard Medical School Affiliate

Welcome to the Joslin Research Website


	Joslin Investigator:

Dr. Laurie J. Goodyear

Investigator Specifics:

Professional Details:

Member of Section:

Current Fellows, Students, or Lab Members:

Vichaiwong Kanokwan, MS

Ho-Jin Koh

Henning Fritz Kramer

Jan-Willem Middelbeek, M.D.

Katja S.C. Roeckl, MD

Past Fellows, etc.:

Oscar Alcazar

William Aschenbach

Josef Brandauer

Richard Ho

Kirsten Howlett

Niels Jessen, MD

Allison Jozsi

Yasuko Manabe

Nicolas Musi

Erik Rocheford

Kei Sakamoto

Investigators

Adjunct Investigators

Fellows & Team Members

DERC Cores

Research Sections

Joslin Resources

Laurie J Goodyear, PhD

Investigator

Joslin Diabetes Center

Section Head: Metabolism

Joslin Diabetes Center

Core Director

Transgenic Core - Joslin Diabetes Center

10/1/1990 -

The Effects of Excercise

The Goodyear lab is working to define the cellular signaling mechanisms that occur within muscle cells during exercise and how these mechanisms regulate numerous metabolic processes such as glucose uptake and glycogen synthesis.

Exercise is an important component in the treatment of diabetes. Exercise has insulin-like effects to stimulate the uptake of glucose into the contracting muscles. Regular exercise also has many other effects in people such as lowering blood pressure, improving lipid levels and lowering the risk of heart disease.

To understand how exercise promotes these beneficial effects, the Goodyear lab studies numerous cellular signaling molecules that are activated during exercise and evaluates how the activation of these molecules regulates metabolic processes such as glucose uptake and the synthesis and degradation of glycogen. The lab also studies how exercise regulates the rates of gene transcription involved in the synthesis of proteins. Examples of signaling molecules that are under investigation at the present time are the AMPK, MAPK, IRS-1, IRS-2, AKT, JNK, NOS, glycogen synthase, glycogen phosphorylase, GSK-3, among others.

GENERAL PROJECTS:

- Regulation of glucose transport in skeletal muscle

- Mechanism of contraction-stimulated glucose metabolism in skeletal muscle

- Regulation of glycogen synthesis in contracting skeletal muscle

- Molecular signaling of exercise and muscle contraction to modulate gene transcription in skeletal muscle